RNA Details
Disease Name
non-alcoholic fatty liver disease
Tissue
liver
RNA Symbol
mir-21a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
H&E staining; RT-PCR; immunofluorescence etc.
Target
PPARA
Pathway
PPAR SIGNALING PATHWAY
PubMed ID
Title
Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARalfa expression
Year
2016
Function
"Liver microrna-21 overexpression in non-alcoholic steatohepatitis, inhibition of ppara, promotion of hepatocyte injury, inflammation and fibrosis."